Hypermutable minisatellites, a human affair?

  title={Hypermutable minisatellites, a human affair?},
  author={Philippe R. J. Bois},
  volume={81 4},
Minisatellites are a class of highly polymorphic GC-rich tandem repeats. They include some of the most variable loci in the human genome, with mutation rates ranging from 0.5% to >20% per generation. Structurally, they consist of 10- to 100-bp intermingled variant repeats, making them ideal tools for dissecting mechanisms of instability at tandem repeats. Distinct mutation processes generate rare intra-allelic somatic events and frequent complex conversion-like germline mutations in these… CONTINUE READING

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