Hypermutability of homonucleotide runs in mismatch repair and DNA polymerase proofreading yeast mutants.

@article{Tran1997HypermutabilityOH,
  title={Hypermutability of homonucleotide runs in mismatch repair and DNA polymerase proofreading yeast mutants.},
  author={Huong Thi Thu Tran and John D. Keen and M C Kricker and Michael A. Resnick and Dmitry A Gordenin},
  journal={Molecular and cellular biology},
  year={1997},
  volume={17 5},
  pages={2859-65}
}
Homonucleotide runs in coding sequences are hot spots for frameshift mutations and potential sources of genetic changes leading to cancer in humans having a mismatch repair defect. We examined frameshift mutations in homonucleotide runs of deoxyadenosines ranging from 4 to 14 bases at the same position in the LYS2 gene of the yeast Saccharomyces cerevisiae. In the msh2 mismatch repair mutant, runs of 9 to 14 deoxyadenosines are 1,700-fold to 51,000-fold, respectively, more mutable for single… CONTINUE READING
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