Hypermobile Ehlers–Danlos syndrome (a.k.a. Ehlers–Danlos syndrome Type III and Ehlers–Danlos syndrome hypermobility type): Clinical description and natural history

  title={Hypermobile Ehlers–Danlos syndrome (a.k.a. Ehlers–Danlos syndrome Type III and Ehlers–Danlos syndrome hypermobility type): Clinical description and natural history},
  author={Brad T Tinkle and Marco Castori and Britta Berglund and Helen Cohen and Rodney Grahame and Hanadi Kazkaz and Howard P. Levy},
  journal={American Journal of Medical Genetics Part C: Seminars in Medical Genetics},
  pages={48 - 69}
  • B. Tinkle, M. Castori, H. Levy
  • Published 1 March 2017
  • Medicine
  • American Journal of Medical Genetics Part C: Seminars in Medical Genetics
The hypermobile type of Ehlers–Danlos syndrome (hEDS) is likely the most common hereditary disorder of connective tissue. It has been described largely in those with musculoskeletal complaints including joint hypermobility, joint subluxations/dislocations, as well as skin and soft tissue manifestations. Many patients report activity‐related pain and some go on to have daily pain. Two undifferentiated syndromes have been used to describe these manifestations—joint hypermobility syndrome and hEDS… 

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