Hypermethylation of the tumor suppressor gene PRDM1/Blimp-1 supports a pathogenetic role in EBV-positive Burkitt lymphoma

@inproceedings{Zhang2014HypermethylationOT,
  title={Hypermethylation of the tumor suppressor gene PRDM1/Blimp-1 supports a pathogenetic role in EBV-positive Burkitt lymphoma},
  author={Tianlong Zhang and Jian Feng Ma and Kui Nie and Jean Li Yan and Yang Liu and Carlos Eduardo Bacchi and Eduardo M. Queiroga and Gabriela Gualco and Jeffery T. Sample and Attilio Orazi and Daniel M. Knowles and Wayne Tam},
  booktitle={Blood cancer journal},
  year={2014}
}
PRDM1/Blimp-1 is a tumor suppressor gene in the activated B-cell subtype of diffuse large B-cell lymphomas. Its inactivation contributes to pathogenesis in this setting by impairing terminal B-cell differentiation induced by constitutive nuclear factor-κB activation. The role of PRDM1 in Burkitt lymphoma (BL) lymphomagenesis is not known. Here we identified hypermethylation of the promoter region and exon 1 of PRDM1 in all six Epstein-Barr virus (EBV)-positive BL cell lines and 12 of 23 (52… CONTINUE READING
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PRDM1 is a tumor suppressor gene in natural killer cell malignancies.

Proceedings of the National Academy of Sciences of the United States of America • 2011

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