Hypermethylation of the spleen tyrosine kinase promoter in T-lineage acute lymphoblastic leukemia

Abstract

Sequence analysis of the noncoding first exon (exon 1) of the Syk gene demonstrated the presence of a previously cloned CpG island (GenBank #Z 65706). Transient transfection analysis in Daudi cells demonstrated promoter activity (18-fold increase over parental luciferase plasmid) for a 348 bp BstXI–BsrBI fragment containing this island. This region exhibits… (More)
DOI: 10.1038/sj.onc.1206313

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@article{Goodman2003HypermethylationOT, title={Hypermethylation of the spleen tyrosine kinase promoter in T-lineage acute lymphoblastic leukemia}, author={P. A. Goodman and Nicole Y. Burkhardt and Brian D. Juran and Heather E Tibbles and Faith M Uckun}, journal={Oncogene}, year={2003}, volume={22}, pages={2504-2514} }