Hypermethylation of the p15INK4B gene in myelodysplastic syndromes.

  title={Hypermethylation of the p15INK4B gene in myelodysplastic syndromes.},
  author={Toyoaki Uchida and Taroh Kinoshita and Hirokazu Nagai and Yoko Nakahara and Hidetane Saito and Tomomitsu Hotta and Takashi Murate},
  volume={90 4},
Previous studies have shown that the cyclin-dependent kinase inhibitor (CDKI) genes p15INK4B and p16INK4A are frequently inactivated by genetic alterations in many malignant tumors and that they are candidate tumor-suppressor genes. Although genetic alterations in these genes may be limited to lymphoid malignancies, it has been reported that their inactivation by aberrant methylation of 5' CpG islands may be involved in various hematologic malignancies. In this study, we investigated the… CONTINUE READING
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Frequent hypermethylation of p 16 and p 15 genes in 16 ) , and retained the stable clinical status . These results multiple myeloma

  • JM Bennett, D Catovsky, MT Daniel, G Flandrin, HR Gralnick
  • Blood
  • 1997

Mutational analysis of the p 15 and p 16 genes in acute leukaemias

  • Issa JPJ, YL Ottaviano, P Celano, Hamilton, DavidsonCross NCP
  • Br J Haematol
  • 1996

Role of the cyclin - dependent kinase 10 % of patients evolved to OL and had poor prognosis . So , inhibitors in the development of cancer

  • DP Huang
  • Blood
  • 1995

horn S : ‘ ‘ Exclusive ’ ’ p 15 INK 4 B gene deletion in acute lymphocytic leukemia include the E 1 b exon of the p 16 INK 4 A gene

  • M Heyman, O Rasool, +11 authors MA Boogaerts
  • Haematol
  • 1995

Deletions of the cyclin - dependent kinase4 inhibitor gene in As shown in Figs 2 and 3 , hypermethylation of the multiple human cancers

  • A Bird
  • Nature
  • 1994

In the present study , we calculated the ratio with a minor A cell cycle regulator potentially involved in genesis of many tumor modification because the p 15 probe had a tendency to hybridtypes

  • SV Tavtigian, E Stockert, BE Johnson, MH Skolnick
  • Science
  • 1994

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