Hypermethylation of the hMLH1 promoter with absent hMLH1 expression in medullary-type poorly differentiated colorectal adenocarcinoma in the elderly

@article{Arai2004HypermethylationOT,
  title={Hypermethylation of the hMLH1 promoter with absent hMLH1 expression in medullary-type poorly differentiated colorectal adenocarcinoma in the elderly},
  author={Tomio Arai and Yukiyoshi Esaki and M Sawabe and Naoko Honma and Ken-ichi Nakamura and K Takubo},
  journal={Modern Pathology},
  year={2004},
  volume={17},
  pages={172-179}
}
To clarify the significance of hMLH1 promoter hypermethylation in the development of medullary-type poorly differentiated colorectal adenocarcinoma, we studied the status of promoter methylation and hMLH1 expression in 23 medullary-type and 12 pleomorphic-type carcinomas, as well as the pathology and microsatellite status. In medullary-type carcinomas, the percentages of cases with promoter methylation (83%) and an absence of hMLH1 expression (91%) were significantly higher than in pleomorphic… CONTINUE READING
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