Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability.

@article{Fleisher1999HypermethylationOT,
  title={Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability.},
  author={Albert Steven Fleisher and Manel Esteller and Suna Wang and Gen Tamura and Hiromu Suzuki and Jie‐yun Yin and Tong Tong Zou and Joshua Matt Abraham and Dehe Kong and Kara N. Smolinski and Yu Qian Shi and Mun Gan Rhyu and Steven M. Powell and Stephen P. James and Keith T Wilson and James G. Herman and Stephen J. Meltzer},
  journal={Cancer research},
  year={1999},
  volume={59 5},
  pages={
          1090-5
        }
}
Human gastric carcinoma shows a higher prevalence of microsatellite instability (MSI) than does any other type of sporadic human cancer. The reasons for this high frequency of MSI are not yet known. In contrast to endometrial and colorectal carcinoma, mutations of the DNA mismatch repair (MMR) genes hMLH1 or hMSH2 have not been described in gastric carcinoma. However, hypermethylation of the hMLH1 MMR gene promoter is quite common in MSI-positive endometrial and colorectal cancers. This… CONTINUE READING

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