Hypermethylation of the calcitonin gene in acute lymphoblastic leukaemia is associated with unfavourable clinical outcome

@article{Romn2001HypermethylationOT,
  title={Hypermethylation of the calcitonin gene in acute lymphoblastic leukaemia is associated with unfavourable clinical outcome},
  author={J. Rom{\'a}n and J. A. Castillejo and A. Jim{\'e}nez and R. Bornstein and M. G. Gonz{\'a}lez and M. del Carmen Rodr{\'i}guez and M. Barrios and J. Maldonado and A. Torres},
  journal={British Journal of Haematology},
  year={2001},
  volume={113}
}
We analysed calcitonin (CALC1) gene hypermethylation using semiquantitative differential polymerase chain reaction in 105 patients with adult (n = 49) and childhood (n = 56) acute lymphoblastic leukaemia (ALL), and studied the association of CALC1 hypermethylation with clinical presentation features and disease outcome. We also investigated the possible relationship between CALC1 methylation status and expression of the cell cycle inhibitor gene p57KIP2. We observed CALC1 hypermethylation in… Expand
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