Hypermethylation of the calcitonin gene in acute lymphoblastic leukaemia is associated with unfavourable clinical outcome.

@article{Romn2001HypermethylationOT,
  title={Hypermethylation of the calcitonin gene in acute lymphoblastic leukaemia is associated with unfavourable clinical outcome.},
  author={Jos{\'e} Rom{\'a}n and Juan Antonio Castillejo and Antonio Jim{\'e}nez and Rafael Bornstein and Mar{\'i}a Gracia Bagur Gonz{\'a}lez and Mar{\'i}a del Carmen Rodr{\'i}guez and Manuel Barrios and J. Maldonado and Ant{\^o}nio Torres},
  journal={British journal of haematology},
  year={2001},
  volume={113 2},
  pages={
          329-38
        }
}
We analysed calcitonin (CALC1) gene hypermethylation using semiquantitative differential polymerase chain reaction in 105 patients with adult (n = 49) and childhood (n = 56) acute lymphoblastic leukaemia (ALL), and studied the association of CALC1 hypermethylation with clinical presentation features and disease outcome. We also investigated the possible relationship between CALC1 methylation status and expression of the cell cycle inhibitor gene p57KIP2. We observed CALC1 hypermethylation in… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 14 CITATIONS

Methylation pattern of calcitonin (CALCA) gene in pediatric acute leukemia.

  • Journal of pediatric hematology/oncology
  • 2011
VIEW 5 EXCERPTS
CITES RESULTS & BACKGROUND
HIGHLY INFLUENCED