Hypermethylation of the CpG islands in the promoter region flanking GSTP1 gene is a potential plasma DNA biomarker for detecting prostate carcinoma.

@article{Chuang2007HypermethylationOT,
  title={Hypermethylation of the CpG islands in the promoter region flanking GSTP1 gene is a potential plasma DNA biomarker for detecting prostate carcinoma.},
  author={Cheng-Keng Chuang and D C Chu and Ron-Dar Tzou and Shu-I Liou and J H Chia and C G Sun},
  journal={Cancer detection and prevention},
  year={2007},
  volume={31 1},
  pages={59-63}
}
OBJECTIVES To investigate the possibility of identifying DNA hypermethylation in the circulation of prostate cancer patients. METHODS Plasma DNA samples were extracted from 36 prostate cancer patients and 27 benign prostate hyperplasia (BPH) cases. After extensive methylation-sensitive restriction enzyme digestion, the DNA samples were subjected to the real-time quantitative PCR amplification. Dissociation curve analysis was applied to determine if hypermethylation occurred in the promoter… CONTINUE READING

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