Hypermethylation of the AKAP12 promoter is a biomarker of Barrett's-associated esophageal neoplastic progression.

@article{Jin2008HypermethylationOT,
  title={Hypermethylation of the AKAP12 promoter is a biomarker of Barrett's-associated esophageal neoplastic progression.},
  author={Zhe Jin and James Peter Hamilton and Jian Yang and Yuriko Mori and Alexandru V. Olaru and Fumiaki Sato and Tetsuo Ito and Takatsugu Kan and Yulan Cheng and Bogdan C. Paun and Stefan David and David G Beer and Rachana Agarwal and John M. Abraham and Stephen J. Meltzer},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2008},
  volume={17 1},
  pages={111-7}
}
The A-kinase anchoring protein 12 (AKAP12) is a kinase scaffold protein with known tumor suppressor activity. Recently, AKAP12 promoter hypermethylation was reported in gastric and colorectal cancers. We examined AKAP12 promoter hypermethylation using real-time methylation-specific PCR in 259 human esophageal tissues. AKAP12 hypermethylation showed highly… CONTINUE READING