Hypermethylation of the 5' CpG island of the FHIT gene is associated with hyperdiploid and translocation-negative subtypes of pediatric leukemia.

@article{Zheng2004HypermethylationOT,
  title={Hypermethylation of the 5' CpG island of the FHIT gene is associated with hyperdiploid and translocation-negative subtypes of pediatric leukemia.},
  author={Shichun Zheng and Xiaomei Ma and Luoping Zhang and Laura Gunn and Martyn T Smith and Joseph Wiemels and Kenneth Wong Pak Leung and Patricia A. Buffler and John K. Wiencke},
  journal={Cancer research},
  year={2004},
  volume={64 6},
  pages={2000-6}
}
The human FHIT (fragile histidine triad) gene is a putative tumor suppressor gene located at chromosome region 3p14.2. Previous studies have shown that loss of heterozygosity, homozygous deletions, and abnormal expression of the FHIT gene are involved in several types of human malignancies. A CpG island is present in the 5' promoter region of the FHIT gene, and methylation in this region correlates with loss of FHIT expression. To test whether aberrant methylation of the FHIT gene may play a… CONTINUE READING