Hypermethylation of hepatic Gck promoter in ageing rats contributes to diabetogenic potential

@article{Jiang2008HypermethylationOH,
  title={Hypermethylation of hepatic Gck promoter in ageing rats contributes to diabetogenic potential},
  author={Mei Hua Jiang and Jing Fei and M. S. Lan and Zhi-hua Lu and Ming Liu and Wei Wei Fan and Xiang Gao and Daniel R Lu},
  journal={Diabetologia},
  year={2008},
  volume={51},
  pages={1525-1533}
}
Hepatic glucokinase (GCK) is a key enzyme in glucose utilisation. Downregulation of its activity is associated with insulin resistance and type 2 diabetes mellitus. However, it is unknown whether hepatic Gck expression is influenced by age and is involved in ageing-mediated diabetes, and whether the degree of methylation of the hepatic Gck promoter is correlated with the transcription of Gck. To address the question, we evaluated hepatic Gck transcription and promoter methylation in young (14… CONTINUE READING

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