Hypermethylation of HIC1 Promoter and Aberrant Expression of HIC1/SIRT1 Might Contribute to the Carcinogenesis of Pancreatic Cancer

@article{Zhao2012HypermethylationOH,
  title={Hypermethylation of HIC1 Promoter and Aberrant Expression of HIC1/SIRT1 Might Contribute to the Carcinogenesis of Pancreatic Cancer},
  author={Gang Zhao and Qi Qin and Jungang Zhang and Yang Liu and Shichang Deng and Lin Wei Liu and Bo Wang and Kui Tian and Chun-you Wang},
  journal={Annals of Surgical Oncology},
  year={2012},
  volume={20},
  pages={301-311}
}
DNA hypermethylation is proved to be involved in carcinogenesis. Because chronic pancreatitis (CP) is a consistent risk factor for pancreatic cancer, the possible alteration and tumor contribute effects of hypermethylated in cancer-1 (HIC1) promoter methylation in CP was investigated. Methylation of HIC1 promoter HIC1 and SIRT1 expression were detected in human normal pancreas (NP), CP and pancreatic adenocarcinoma tissues. Furthermore, HIC1/SIRT1 pathway was regulated by demethylating reagent… CONTINUE READING
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