Hypermethylation of Fads2 and altered hepatic fatty acid and phospholipid metabolism in mice with hyperhomocysteinemia.

@article{Devlin2007HypermethylationOF,
  title={Hypermethylation of Fads2 and altered hepatic fatty acid and phospholipid metabolism in mice with hyperhomocysteinemia.},
  author={Angela M. Devlin and Ranji Singh and Rachel E Wade and Sheila Margaret Innis and Teodoro G Bottiglieri and Steven R Lentz},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 51},
  pages={37082-90}
}
Alterations in lipid metabolism may play a role in the vascular pathology associated with hyperhomocysteinemia (HHcy). Homocysteine is linked to lipid metabolism through the methionine cycle and the synthesis of phosphatidylcholine (PC) by phosphatidylethanolamine (PE) methyltransferase, which is responsible for the synthesis of 20-40% of liver PC. The goal of the present study was to determine if the reduced methylation capacity in HHcy is associated with alterations in liver phospholipid and… CONTINUE READING
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