Hypermethylation of E-cadherin in leukemia.

  title={Hypermethylation of E-cadherin in leukemia.},
  author={John R Melki and Paul C Vincent and Ross D. Brown and Susan J. Clark},
  volume={95 10},
E-cadherin gene is often termed a "metastasis suppressor" gene because the E-cadherin protein can suppress tumor cell invasion and metastasis. Inactivation of the E-cadherin gene occurs in undifferentiated solid tumors by both genetic and epigenetic mechanisms; however, the role of E-cadherin in hematologic malignancies is only now being recognized. E-cadherin expression is essential for erythroblast and normoblast maturation, yet expression is reduced or absent in leukemic blast cells. This… CONTINUE READING
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