Hypermethylation of E-cadherin in leukemia.

@article{Melki2000HypermethylationOE,
  title={Hypermethylation of E-cadherin in leukemia.},
  author={John R Melki and Paul C Vincent and Ross D. Brown and Susan J. Clark},
  journal={Blood},
  year={2000},
  volume={95 10},
  pages={3208-13}
}
E-cadherin gene is often termed a "metastasis suppressor" gene because the E-cadherin protein can suppress tumor cell invasion and metastasis. Inactivation of the E-cadherin gene occurs in undifferentiated solid tumors by both genetic and epigenetic mechanisms; however, the role of E-cadherin in hematologic malignancies is only now being recognized. E-cadherin expression is essential for erythroblast and normoblast maturation, yet expression is reduced or absent in leukemic blast cells. This… CONTINUE READING
64 Citations
33 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 64 extracted citations

References

Publications referenced by this paper.

Similar Papers

Loading similar papers…