Hypermethylation of APC promoter 1A is associated with moderate activation of Wnt signalling pathway in a subset of colorectal serrated adenomas.

@article{Fu2009HypermethylationOA,
  title={Hypermethylation of APC promoter 1A is associated with moderate activation of Wnt signalling pathway in a subset of colorectal serrated adenomas.},
  author={Xiangsheng Fu and Jing Li and Kang Li and Xiaoxiao Tian and Yali Zhang},
  journal={Histopathology},
  year={2009},
  volume={55 5},
  pages={554-63}
}
AIMS The role of Wnt signalling pathway in serrated adenomas (SAs) remains to be identified. The aim of this study was to determine whether Wnt signalling plays a role in the pathogenesis of SAs, and to clarify the mechanism of Wnt signalling activation in SAs. METHODS AND RESULTS This study investigated immunoreactivities of adenomatous polyposis coli (APC) and beta-catenin, mutations of APC and beta-catenin genes, methylation status of APC promoter 1A in 12 SAs, and compared the findings… CONTINUE READING