Hypermethylation in histologically distinct classes of breast cancer.

  title={Hypermethylation in histologically distinct classes of breast cancer.},
  author={Young Kyung Bae and Amy Brown and Elizabeth Garrett and Daniel M. Bornman and Mary Jo Fackler and Saraswati V. Sukumar and James G. Herman and Edward W. Gabrielson},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={10 18 Pt 1},
PURPOSE A number of different genes are known to be inactivated by aberrant hypermethylation in breast cancer, but it is still unknown to what extent these epigenetic alterations differ according to specific breast cancer phenotypes. We sought to determine whether the extent of hypermethylation or defined profiles of gene hypermethylation are associated with biological characteristics of breast cancers. EXPERIMENTAL DESIGN We evaluated methylation status of 12 different genes in a series of… CONTINUE READING


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Identification and characterization of differentially methylated regions of genomic DNA by methylation-sensitive arbitrarily primed PCR

  • ML Gonzalgo, G Liang, Spruck CH 3rd, JM Zingg, Rideout WM 3rd, PA Jones
  • Cancer Res
  • 1997
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