Hypermethylation contributes to down-regulation of lysosomal β-hexosaminidase α subunit in prostate cancer cells.

Abstract

β-Hexosaminidase, involved in degradation of glycoproteins and glycosphingolipids, is altered in several tumours leading to enhanced migration capacity. To date, the expression of the β-hexosaminidase isoenzymes in prostate cancer cells has not been elucidated. By using PC3, LNCaP, DUCaP, MDAPCa 2b, and hyperplasic prostate (BPH-1) cell lines, we analysed… (More)
DOI: 10.1016/j.biochi.2013.12.016

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