Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia.

@article{Myhnen1998HypermethylationCS,
  title={Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia.},
  author={Sanna K. My{\"o}h{\"a}nen and Stephen B. Baylin and James G. Herman},
  journal={Cancer research},
  year={1998},
  volume={58 4},
  pages={
          591-3
        }
}
Inactivation of p16ink4A and other tumor suppressor genes has been associated with promoter region hypermethylation in neoplasia. However, direct proof for aberrant DNA methylation as an independent event for loss of gene function has been difficult to obtain. We addressed this question in the colon carcinoma cell line HCT116, which contains one allele of p16ink4A with a coding region frameshift mutation and one wild-type allele. Neither allele contains a mutation in the proximal promoter… CONTINUE READING

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