Hypermethylation-associated transcriptional silencing of E-cadherin in primary sporadic colorectal carcinomas.

@article{Garinis2002HypermethylationassociatedTS,
  title={Hypermethylation-associated transcriptional silencing of E-cadherin in primary sporadic colorectal carcinomas.},
  author={George A Garinis and Panayiotis G. Menounos and Nick E. Spanakis and Kostas Papadopoulos and George Karavitis and Ismailou Parassi and Evangelia Christeli and George P. Patrinos and Evangelos N. Manolis and George Peros},
  journal={The Journal of pathology},
  year={2002},
  volume={198 4},
  pages={442-9}
}
Loss of E (epithelial)-cadherin expression has been previously documented in sporadic colorectal carcinomas (SCRCs), but not as a consequence of mutations or allelic loss. In this study, the methylation status of the E-cadherin promoter was examined by utilizing the methylation-specific polymerase chain reaction (MSP) assay in 63 primary SCRCs and paired adjacent normal tissues. This was correlated with E-cadherin expression at both the RNA and the protein levels using multiplex reverse… CONTINUE READING
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