Hypermethylation-associated inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human pancreatic cancers.

@article{Komazaki2004HypermethylationassociatedIO,
  title={Hypermethylation-associated inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human pancreatic cancers.},
  author={Toshiaki Komazaki and Hisaki Nagai and Mitsuru Emi and Yoshie Terada and Aya Yabe and Enjing Jin and Ooiti Kawanami and Noboru Konishi and Yoshinori Moriyama and Tetsuji Naka and Tadamitsu Kishimoto},
  journal={Japanese journal of clinical oncology},
  year={2004},
  volume={34 4},
  pages={
          191-4
        }
}
BACKGROUND SOCS-1, a JAK-binding protein (SSI-1/SOCS-1/JAB), regulates the JAK/STAT signal transduction pathway that relays signals from various cytokines in the extracellular matrix into the cell. Inactivation of the SOCS-1 gene by methylation has been previously described in hepatocellular carcinomas and multiple myeloma. The purpose of the present work was to analyze the expression of the SOCS-1 gene and identify inactivation of this gene by methylation in pancreatic cancers. METHODS 20… CONTINUE READING

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