Hypermethylation and transcriptional downregulation of the CITED4 gene at 1p34.2 in oligodendroglial tumours with allelic losses on 1p and 19q

@article{Tews2007HypermethylationAT,
  title={Hypermethylation and transcriptional downregulation of the CITED4 gene at 1p34.2 in oligodendroglial tumours with allelic losses on 1p and 19q},
  author={Bj{\"o}rn Tews and Peter Roerig and Cord Hartmann and Meinhard Hahn and Joerg Felsberg and Britta Blaschke and Michael Christoph Sabel and Annegret Kunitz and Grischa Toedt and Kai Neben and Axel Benner and Andreas von Deimling and Guido Reifenberger and Peter Lichter},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={5010-5016}
}
Deletions of chromosomal arms 1p and 19q are frequent in oligodendroglial tumours and have been associated with sensitivity to radio- and chemotherapy as well as favourable prognosis. By using microarray-based expression profiling, we found that oligodendroglial tumours with 1p and 19q losses showed significantly lower expression of the CBP/p300-interacting transactivator with glutamic acid/aspartic acid-rich carboxyl-terminal domain 4 gene (CITED4) at 1p34.2 as compared to tumours without 1p… CONTINUE READING

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