Hypermethylation and loss of heterozygosity of tumor suppressor genes on chromosome 3p in cervical cancer.

@article{Choi2007HypermethylationAL,
  title={Hypermethylation and loss of heterozygosity of tumor suppressor genes on chromosome 3p in cervical cancer.},
  author={Chel Hun Choi and Kyung-Mee Lee and J Choi and Tae Joong Kim and Woo Young Kim and Jeong Won Lee and Sun-Joo Lee and Je-Ho Lee and D. H. Bae and Byoung Gie Kim},
  journal={Cancer letters},
  year={2007},
  volume={255 1},
  pages={26-33}
}
We examined the promoter methylation status and LOH of the chromosome 3p genes, von Hippel-Lindau disease (VHL), retinoic acid receptor beta (RAR-beta), RAS association domain family 1A (RASSF1A), and fragile histidine triad (FHIT), in 37 samples of cervical squamous cell carcinoma and corresponding noncancerous tissues. We also analyzed the expression of RAR-beta protein by immunohistochemistry. Promoter hypermethylation in RAR-beta and FHIT was detected in 41% and 24% of tumors, respectively… CONTINUE READING

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