Hyperlipidemia promotes osteoclastic potential of bone marrow cells ex vivo.

@article{Tintut2004HyperlipidemiaPO,
  title={Hyperlipidemia promotes osteoclastic potential of bone marrow cells ex vivo.},
  author={Yin Tintut and Sean E Morony and Linda L. Demer},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2004},
  volume={24 2},
  pages={e6-10}
}
OBJECTIVE Osteoporosis is associated epidemiologically with atherosclerosis and hyperlipidemia. We previously found that atherogenic lipids regulate bone formation. To determine whether hyperlipidemia also affects bone resorption, we compared osteoclastogenesis in marrow preosteoclasts derived from hyperlipidemic versus control mice. METHODS Nonadherent marrow cells from low-density lipoprotein receptor-/- (LDLR-/-)and C57BL/6J mice were cultured with M-CSF and ligand for receptor activator… CONTINUE READING

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Atherogenic high-fat diet reduces bone mineralization in mice.

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