Hyperleukocytic leukemias and leukostasis: a review of pathophysiology, clinical presentation and management.

@article{Porcu2000HyperleukocyticLA,
  title={Hyperleukocytic leukemias and leukostasis: a review of pathophysiology, clinical presentation and management.},
  author={Pierluigi Porcu and Larry Dean Cripe and Ee Wan. Ng and Shailender Bhatia and Cindy M Danielson and Attilio Orazi and L. J. Mccarthy},
  journal={Leukemia & lymphoma},
  year={2000},
  volume={39 1-2},
  pages={
          1-18
        }
}
Acute hyperleukocytic leukemias (AHL) are associated with a very high early mortality rate mostly due to respiratory failure or intracranial bleeding. The pathophysiological process leading to these complications is called leukostasis but the biological mechanisms underlying its development and progression remain unclear. Although traditionally related to "over-crowding" of leukemic blasts in the capillaries of the microcirculation, leukostasis is likely to result from direct endothelial cell… CONTINUE READING
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