Hyperketonemia (acetoacetate) increases the oxidizability of LDL + VLDL in Type-I diabetic patients.

@article{Jain1998HyperketonemiaI,
  title={Hyperketonemia (acetoacetate) increases the oxidizability of LDL + VLDL in Type-I diabetic patients.},
  author={Sushil K. Jain and Robert Mcvie and John J Jaramillo and Yuming Chen},
  journal={Free radical biology & medicine},
  year={1998},
  volume={24 1},
  pages={175-81}
}
The reason for the disproportionately higher level of vascular disease in patients with diabetes is not known. Oxidative modification of low-density lipoproteins has been implicated in impaired cholesterol uptake and its deposition in the arterial wall and atherosclerosis. The present study has examined the effects of hyperketonemia, glycemic control and duration of diabetes on the in vitro oxidative susceptibility to Cu++ of low-density lipoprotein (LDL) + very low-density lipoprotein (VLDL… CONTINUE READING
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