Hyperinsulinemia in hypertension: Increased secretion, reduced clearance or both?

  title={Hyperinsulinemia in hypertension: Increased secretion, reduced clearance or both?},
  author={Dario Giugliano and Antonio Quatraro and Arcangelo Minei and Nicla de Rosa and Ludovico Coppola and F D'onofrio},
  journal={Journal of endocrinological investigation},
  volume={16 5},
Peripheral hyperinsulinism is said to be associated and perhaps implicated in the pathogenesis of hypertension. There is however some inconsistency in the evidence of the relationship between insulin and blood pressure. We prospectively investigated glucose metabolism, insulin and C-peptide values and serum lipids in a large sample of hypertensive as compared with age and body habitus-matched normotensive subjects. As a group, the 145 hypertensives (blood pressure: 160/99 +/- 8.5/6.5 mmHg, mean… CONTINUE READING


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