Hyperinsulinemia in a normal population as a predictor of non-insulin-dependent diabetes mellitus, hypertension, and coronary heart disease: the Barilla factory revisited.

@article{Zavaroni1999HyperinsulinemiaIA,
  title={Hyperinsulinemia in a normal population as a predictor of non-insulin-dependent diabetes mellitus, hypertension, and coronary heart disease: the Barilla factory revisited.},
  author={Ivana Zavaroni and Luisa Bonini and Paola Gasparini and Angela Luciana Barilli and Alessandra Zuccarelli and Elisabetta Dall'aglio and Roberto Delsignore and Gerald Mark Reaven},
  journal={Metabolism: clinical and experimental},
  year={1999},
  volume={48 8},
  pages={
          989-94
        }
}
The study was initiated to evaluate the ability of hyperinsulinemia (as a surrogate measure of insulin resistance) to predict the development in a previously healthy population of three putative outcomes of this abnormality--glucose intolerance, hypertension, and coronary heart disease (CHD). The study involved defining the incidence at which these changes occurred between 1981 and 1993 to 1996 in 647 individuals who were free of any disease when initially studied. The study population… CONTINUE READING
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