Hyperinsulinemia and its impact on obesity and insulin resistance.

@article{Cusin1992HyperinsulinemiaAI,
  title={Hyperinsulinemia and its impact on obesity and insulin resistance.},
  author={Isabelle Cusin and Françoise Rohner-Jeanrenaud and Johann Terrettaz and Bernard Jeanrenaud},
  journal={International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity},
  year={1992},
  volume={16 Suppl 4},
  pages={
          S1-11
        }
}
The impact of hyperinsulinemia on the establishment of insulin resistance was investigated. This was done by treating normal rats with insulin for 3-4 days via osmotic minipumps, and by comparing them with saline-treated controls. Hyperinsulinemia produced by prior insulin treatment (i.e. prior insulinization of the normal rats) resulted in a well tolerated hypoglycemia, increased food intake and body weight gain. Euglycemic-hyperinsulinemic clamps were carried out at the end of the… CONTINUE READING

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