Hyperinflation, dyspnea, and exercise intolerance in chronic obstructive pulmonary disease.

@article{ODonnell2006HyperinflationDA,
  title={Hyperinflation, dyspnea, and exercise intolerance in chronic obstructive pulmonary disease.},
  author={Denis E O'Donnell},
  journal={Proceedings of the American Thoracic Society},
  year={2006},
  volume={3 2},
  pages={
          180-4
        }
}
Expiratory flow limitation is the pathophysiologic hallmark of chronic obstructive pulmonary disease (COPD), but dyspnea (breathlessness) is its most prominent and distressing symptom. Acute dynamic lung hyperinflation, which refers to the temporary increase in operating lung volumes above their resting value, is a key mechanistic consequence of expiratory flow limitation, and has serious mechanical and sensory repercussions. It is associated with excessive loading and functional weakness of… CONTINUE READING

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