Hyperinflation, dyspnea, and exercise intolerance in chronic obstructive pulmonary disease.

@article{ODonnell2006HyperinflationDA,
  title={Hyperinflation, dyspnea, and exercise intolerance in chronic obstructive pulmonary disease.},
  author={Denis E. O’Donnell},
  journal={Proceedings of the American Thoracic Society},
  year={2006},
  volume={3 2},
  pages={
          180-4
        }
}
  • D. O’Donnell
  • Published 2006
  • Medicine
  • Proceedings of the American Thoracic Society
Expiratory flow limitation is the pathophysiologic hallmark of chronic obstructive pulmonary disease (COPD), but dyspnea (breathlessness) is its most prominent and distressing symptom. Acute dynamic lung hyperinflation, which refers to the temporary increase in operating lung volumes above their resting value, is a key mechanistic consequence of expiratory flow limitation, and has serious mechanical and sensory repercussions. It is associated with excessive loading and functional weakness of… Expand

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TLDR
The role of dynamic hyperinflation in exercise limitation in chronic obstructive pulmonary disease (COPD) remains to be defined and the extent of DH during exercise in COPD correlated best with resting IC. Expand
Lung-volume reduction improves dyspnea, dynamic hyperinflation, and respiratory muscle function.
TLDR
Successful LVRS improves not only lung recoil, but also respiratory muscle function, and reduces dynamic hyperinflation, which helps explain the decreased dyspnea and improved exercise capacity seen after LVRS, and add to current understanding of the mechanisms by which this procedure may help selected patients with severe emphysema. Expand
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Improved exercise endurance during hyperoxia was explained, in part, by a combination of reduced ventilatory demand, improved operational lung volumes, and dyspnea alleviation. Expand
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TLDR
Compensatory phenomena appear to counterbalance the deleterious effects of hyperinflation on the contractility and inspiratory action of the diaphragm in patients with COPD, and cast doubt on the existence of chronic fatigue in well-nourished patients with stable COPD and therefore on the need for therapeutic interventions aimed at improving diaphragem function. Expand
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TLDR
Inspiratory pressure support can reduce breathlessness and increase exercise tolerance to submaximal treadmill exercise in patients with COPD, which could have implications for the rehabilitation of these severely disabled patients. Expand
Dose-response effect of oxygen on hyperinflation and exercise endurance in nonhypoxaemic COPD patients.
TLDR
Oxygen supplementation during exercise induced dose-dependent improvement in endurance and symptom perception in nonhypoxaemic chronic obstructive pulmonary disease patients, which may be partly related to decreased hyperinflation and slower breathing pattern. Expand
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TLDR
In patients with CAL and mild exercise hypoxemia, relief of exertional breathlessness during hyperoxia is explained by reduced ventilatory demand in association with reduced blood lactate levels: Borg, lactate, and VE all fell proportionally duringhyperoxia. Expand
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TLDR
Bronchodilator-induced lung deflation reduced mechanical restriction, increased ventilatory capacity and decreased respiratory discomfort, thereby increasing exercise endurance, and the reduction in dyspnoea ratings at a standardised time correlated with the increased VT. Expand
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TLDR
The qualitatively discrete respiratory sensations of exertional inspiratory difficulty peculiar to patients with CAL may have their origins in thoracic hyperinflation and the resultant disparity between inspiratory effort and ventilatory output. Expand
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TLDR
It is concluded that breathlessness in patients with airways obstruction is not associated with major differences in arterial blood gases or in VO2, VE, f or the pattern of individual breaths; there is a greater degree of airway obstruction and increased inspiratory neuromuscular drive. Expand
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