Hyperinduction of cyclooxygenase-2-mediated proinflammatory cascade: a mechanism for the pathogenesis of avian influenza H5N1 infection.

@article{Lee2008HyperinductionOC,
  title={Hyperinduction of cyclooxygenase-2-mediated proinflammatory cascade: a mechanism for the pathogenesis of avian influenza H5N1 infection.},
  author={Suki Man-Yan Lee and Chung-yan. Cheung and John M. Nicholls and Kenrie P Y Hui and Connie Y. H. Leung and Mongkol Uiprasertkul and George L. Tipoe and Yu-Lung Lau and Leo L. M. Poon and Nancy Y. Ip and Yi Guan and J. S. Malik Peiris},
  journal={The Journal of infectious diseases},
  year={2008},
  volume={198 4},
  pages={
          525-35
        }
}
The mechanism for the pathogenesis of H5N1 infection in humans remains unclear. This study reveals that cyclooxygenase-2 (COX-2) was strongly induced in H5N1-infected macrophages in vitro and in epithelial cells of lung tissue samples obtained during autopsy of patients who died of H5N1 disease. Novel findings demonstrated that COX-2, along with tumor necrosis factor alpha and other proinflammatory cytokines were hyperinduced in epithelial cells by secretory factors from H5N1-infected… 
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