Hyperimmune bovine colostral anti-CS17 antibodies protect against enterotoxigenic Escherichia coli diarrhea in a randomized, doubled-blind, placebo-controlled human infection model.

@article{Savarino2019HyperimmuneBC,
  title={Hyperimmune bovine colostral anti-CS17 antibodies protect against enterotoxigenic Escherichia coli diarrhea in a randomized, doubled-blind, placebo-controlled human infection model.},
  author={Stephen J. Savarino and Robin McKenzie and David R. Tribble and Chad K Porter and Aisling O'Dowd and Stephanie Ann Sincock and Steven Thomas Poole and Barbara Denearing and Colleen M Woods and Hye Jin Kim and Shannon L Grahek and Carl Brinkley and Joseph H. Crabb and August Louis Bourgeois},
  journal={The Journal of infectious diseases},
  year={2019}
}
BACKGROUND Enterotoxigenic Escherichia coli (ETEC) commonly cause diarrhea in children living in developing countries and in travelers' to those regions. ETEC are characterized by colonization factors (CFs) that mediate intestinal adherence. We assessed if bovine colostral IgG (bIgG) antibodies against one CF, CS17, or antibodies against CsbD, the minor tip subunit of CS17, would protect subjects against diarrhea following challenge with a CS17-expressing ETEC strain. METHODS Adult subjects… CONTINUE READING
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