Hypericum perforatum (St John's Wort): a non-selective reuptake inhibitor? A review of the recent advances in its pharmacology

@article{Nathan2001HypericumP,
  title={Hypericum perforatum (St John's Wort): a non-selective reuptake inhibitor? A review of the recent advances in its pharmacology},
  author={P. Nathan},
  journal={Journal of Psychopharmacology},
  year={2001},
  volume={15},
  pages={47 - 54}
}
  • P. Nathan
  • Published 2001
  • Medicine, Psychology
  • Journal of Psychopharmacology
  • Hypericum possesses a unique pharmacology in that it displays the pharmacology of many classes of antidepressants and new mechanisms not typical of standard antidepressants. The most potent of all its action is the moderate to high potency for inhibition of the reuptake of monoamines, serotonin, dopamine and noradrenaline and the amino-acid neurotransmitters GABA and glutamate. Unlike standard reuptake inhibitors, hypericum exerts this reuptake inhibition non-competitively by enhancing… CONTINUE READING
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