Hypericum perforatum (St John's Wort): a non-selective reuptake inhibitor? A review of the recent advances in its pharmacology

@article{Nathan2001HypericumP,
  title={Hypericum perforatum (St John's Wort): a non-selective reuptake inhibitor? A review of the recent advances in its pharmacology},
  author={P. Nathan},
  journal={Journal of Psychopharmacology},
  year={2001},
  volume={15},
  pages={47 - 54}
}
  • P. Nathan
  • Published 2001
  • Chemistry, Medicine
  • Journal of Psychopharmacology
Hypericum possesses a unique pharmacology in that it displays the pharmacology of many classes of antidepressants and new mechanisms not typical of standard antidepressants. The most potent of all its action is the moderate to high potency for inhibition of the reuptake of monoamines, serotonin, dopamine and noradrenaline and the amino-acid neurotransmitters GABA and glutamate. Unlike standard reuptake inhibitors, hypericum exerts this reuptake inhibition non-competitively by enhancing… Expand
An investigation into the acute nootropic effects of Hypericum perforatum L. (St. John's Wort) in healthy human volunteers
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Up-to-date summary of hypericin, its activities and potentials, is aimed to contribute to the process of achieving a new and promising status as an effective agent in medical diagnostic and therapeutic applications. Expand
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Hyperforin, the Active Component of St. John’s Wort, Induces IL-8 Expression in Human Intestinal Epithelial Cells Via a MAPK-Dependent, NF-κB-Independent Pathway
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It is shown that hyperforin, the active component of St. John’s wort, can stimulate interleukin-8 (IL-8) expression in human intestinal epithelia cells (IEC) and primary hepatocytes and induce expression of mRNA, encoding another major inflammatory mediator—intercellular adhesion molecule-1 (ICAM-1). Expand
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