Hypericum perforatum: Pharmacokinetic, Mechanism of Action, Tolerability, and Clinical Drug–Drug Interactions

  title={Hypericum perforatum: Pharmacokinetic, Mechanism of Action, Tolerability, and Clinical Drug–Drug Interactions},
  author={E. Russo and F. Scicchitano and Benjamin J. Whalley and Carmela Mazzitello and M. Ciriaco and S. Esposito and Marinella Patan{\`e} and Roy Upton and M. Pugliese and S. Chimirri and M. Mamm{\`i} and C. Palleria and G. De Sarro},
  journal={Phytotherapy Research},
  • E. Russo, F. Scicchitano, +10 authors G. De Sarro
  • Published 2014
  • Medicine
  • Phytotherapy Research
  • Hypericum perforatum (HP) belongs to the Hypericaceae family and is one of the oldest used and most extensively investigated medicinal herbs. The medicinal form comprises the leaves and flowering tops of which the primary ingredients of interest are naphthodianthrones, xanthones, flavonoids, phloroglucinols (e.g. hyperforin), and hypericin. Although several constituents elicit pharmacological effects that are consistent with HP's antidepressant activity, no single mechanism of action underlying… CONTINUE READING
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