Hypericum perforatum: Pharmacokinetic, Mechanism of Action, Tolerability, and Clinical Drug–Drug Interactions
@article{Russo2014HypericumPP, title={Hypericum perforatum: Pharmacokinetic, Mechanism of Action, Tolerability, and Clinical Drug–Drug Interactions}, author={E. Russo and F. Scicchitano and Benjamin J. Whalley and Carmela Mazzitello and M. Ciriaco and S. Esposito and Marinella Patan{\`e} and Roy Upton and M. Pugliese and S. Chimirri and M. Mamm{\`i} and C. Palleria and G. De Sarro}, journal={Phytotherapy Research}, year={2014}, volume={28} }
Hypericum perforatum (HP) belongs to the Hypericaceae family and is one of the oldest used and most extensively investigated medicinal herbs. The medicinal form comprises the leaves and flowering tops of which the primary ingredients of interest are naphthodianthrones, xanthones, flavonoids, phloroglucinols (e.g. hyperforin), and hypericin. Although several constituents elicit pharmacological effects that are consistent with HP's antidepressant activity, no single mechanism of action underlying… CONTINUE READING
Topics from this paper
108 Citations
A current update on phytochemistry, pharmacology and herb–drug interactions of Hypericum perforatum
- Biology
- Phytochemistry Reviews
- 2017
- 13
Neuroprotective Activity of Hypericum perforatum and Its Major Components
- Medicine
- Front. Plant Sci.
- 2016
- 44
- PDF
Role in depression of a multi-fractionated versus a conventional Hypericum perforatum extract.
- Medicine
- Panminerva medica
- 2018
- 2
No effects of Hypericum-containing complex on dolutegravir plasma trough concentrations: a case report
- Medicine
- European Journal of Clinical Pharmacology
- 2019
- 1
Effects of Hypericum perforatum hydroalcoholic extract, hypericin, and hyperforin on cytotoxicity and CYP3A4 mRNA expression in hepatic cell lines: a comparative study
- Chemistry
- Medicinal Chemistry Research
- 2016
- 1
Hypericum perforatum (St John's wort) beyond depression: A therapeutic perspective for pain conditions.
- Medicine
- Journal of ethnopharmacology
- 2017
- 32
In vitro inhibition of human cytochrome P450 by cudratricusxanthone A.
- Chemistry, Medicine
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- 2015
- 8
Determination of bioactive compounds with benefic potential on health in several medicinal plants
- 2015
- 1
- PDF
The mutagenic, antimutagenic and antioxidant properties of Hypericum lydium
- Chemistry, Medicine
- Pharmaceutical biology
- 2017
- 7
LC-MS/MS based studies on the anti-depressant effect of hypericin in the chronic unpredictable mild stress rat model.
- Medicine
- Journal of ethnopharmacology
- 2015
- 23
References
SHOWING 1-10 OF 230 REFERENCES
A review of clinical and experimental observations about antidepressant actions and side effects produced by Hypericum perforatum extracts.
- Medicine
- Phytomedicine : international journal of phytotherapy and phytopharmacology
- 2003
- 86
Herb–Drug Interactions with St John’s Wort (Hypericum perforatum): an Update on Clinical Observations
- Medicine
- The AAPS Journal
- 2009
- 213
Hyperforin as a possible antidepressant component of hypericum extracts.
- Chemistry, Medicine
- Life sciences
- 1998
- 408
A review of the antibacterial activity of Hypericum perforatum L.
- Biology, Medicine
- Journal of ethnopharmacology
- 2010
- 211
- PDF
Hypericin and pseudohypericin: pharmacokinetics and effects on photosensitivity in humans.
- Medicine
- Pharmacopsychiatry
- 1997
- 178
- Highly Influential
Clinical herbal interactions with conventional drugs: from molecules to maladies.
- Medicine
- Current medicinal chemistry
- 2011
- 89
- Highly Influential
Antidepressant activity of hypericum perforatum and hyperforin: the neglected possibility.
- Medicine
- Pharmacopsychiatry
- 1998
- 207
St John's wort (Hypericum perforatum): drug interactions and clinical outcomes.
- Biology, Medicine
- British journal of clinical pharmacology
- 2002
- 303
Efficacy and tolerability of Hypericum extract for the treatment of mild to moderate depression
- Medicine
- European Neuropsychopharmacology
- 2010
- 102
- PDF