Hypericin inhibits pathological retinal neovascularization in a mouse model of oxygen-induced retinopathy

@article{Higuchi2008HypericinIP,
  title={Hypericin inhibits pathological retinal neovascularization in a mouse model of oxygen-induced retinopathy},
  author={Akiko Higuchi and Haruhiko Yamada and Eri Yamada and Nobuo Jo and Miyo Matsumura},
  journal={Molecular Vision},
  year={2008},
  volume={14},
  pages={249 - 254}
}
PURPOSE Ocular neovascularization is a leading cause of blindness in ischemic retinopathies. Hypericin is an active ingredient in the medical herb St. John's Wort (SJW). Because hypericin inhibits intracellular signaling pathways that are believed to participate in the regulation of angiogenesis, we investigated the actions of hypericin and SJW in retinal neovascularization, using a mouse model of oxygen-induced retinopathy (OIR). METHODS C57BL/6 neonatal mice were exposed to a 75… CONTINUE READING
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John's wort: role of active compounds for its mechanism of action and efficacy

  • V Butterweck, Schmidt MSt
  • Wien Med Wochenschr
  • 2007
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