Hypericin for visualization of high grade gliomas: first clinical experience.

@article{Ritz2012HypericinFV,
  title={Hypericin for visualization of high grade gliomas: first clinical experience.},
  author={Ricky Lee Ritz and Regina G Daniels and Susan Noell and Guenther Christian Feigl and Volker Schmidt and Antje Bornemann and Kristofer Ramina and D. Mayer and Klaus Dietz and Wolfgang S. L. Strauss and Marcos Soares Tatagiba},
  journal={European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology},
  year={2012},
  volume={38 4},
  pages={
          352-60
        }
}
AIMS We aimed to demonstrate that Hypericin, a component of St. Johns Wort, selectively visualizes malignant gliomas. Hypericin is known as one of the most powerful photosensitizers in nature with excellent fluorescent properties. METHODS In five patients with a recurrence of a malignant glioma a newly developed water soluble formulation of hypericin was given intravenously (0.1 mg/kg body weight) 6 h before the surgical procedure. Tumor resection was performed under white light and… CONTINUE READING
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