Hyperhomocysteinemia-induced vascular damage in the minipig. Captopril-hydrochlorothiazide combination prevents elastic alterations.

@article{Rolland1995HyperhomocysteinemiainducedVD,
  title={Hyperhomocysteinemia-induced vascular damage in the minipig. Captopril-hydrochlorothiazide combination prevents elastic alterations.},
  author={Pierre Henri Rolland and Alain Friggi and A. Barlatier and Philippe Piquet and V Latrille and Modou Mbacke Faye and J L Guillou and Philippe Charpiot and Heidi Bodard and Odette Ghiringhelli},
  journal={Circulation},
  year={1995},
  volume={91 4},
  pages={1161-74}
}
BACKGROUND Previous attempts in animals failed to reproduce the metabolic, pathological, and clinical situations encountered in homocystinuric patients. Minipigs on a methionine-rich caseinate-based diet, however, have a special long-lasting postprandial plasma accumulation of methionine, the metabolic precursor of homocysteine. We hypothesized that these minipigs develop hyperhomocysteinemia in the long term. Angiotensin-converting enzyme (ACE) inhibition prevents atherogenic alteration of… CONTINUE READING

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