Hyperhomocysteinemia in chronic renal failure: alternative therapeutic strategies.

  title={Hyperhomocysteinemia in chronic renal failure: alternative therapeutic strategies.},
  author={Alessandra F Perna and Immacolata Sepe and Diana Lanza and Rosa Maria Pollastro and Natale Gaspare De Santo and Diego Ingrosso},
  journal={Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation},
  volume={22 1},
Chronic renal failure and uremia represent states wherein high blood levels of homocysteine, a cardiovascular risk factor, are largely resistant to folate therapy. Indeed, normalization of homocysteine levels through vitamin administration is rarely achieved in this population, and this fact could explain, among other causes, the negative results of intervention trials designed to lower cardiovascular risk. Dialysis itself lowers homocysteine levels, albeit transitorily. N-acetylcysteine… CONTINUE READING