Hyperhomocysteinemia in children treated with sodium valproate and carbamazepine

  title={Hyperhomocysteinemia in children treated with sodium valproate and carbamazepine},
  author={Alberto Verrotti and Raffaele Pascarella and Daniela Trotta and T. Giuva and Guido Morgese and Francesco Chiarelli},
  journal={Epilepsy Research},

Hyperhomocysteinaemia in children receiving phenytoin and carbamazepine monotherapy: a cross-sectional observational study

Phenytoin or carbamazepine monotherapy for >6 months duration is associated with hyperhomocysteinaemia in 90% of North Indian children and Elevated homocysteine concentrations were normalised in these children with folic acid supplementation.

Homocysteine Levels in Epileptic Children Receiving Antiepileptic Drugs

Assessment of plasma homocysteine, serum vitamin B12, and folic acid levels in children receiving enzyme-inducing antiepileptic drugs in children with idiopathic epilepsy is recommended.

Effects of Oxcarbazepine on Plasma Homocysteine, Vitamin B12, Folic Acid Levels

To assess the effects of oxcarbazepine (OXC) on plasma Hcy, FA and vit B12 levels, 42 epileptic outpatients receiving AED therapy were selected and their levels were statistically compared with each other using one way ANOVA method.

Effect of carbamazepine therapy on homocysteine, vitamin B12 and folic acid levels in children with epilepsy

6 months of carbamazepine therapy did not cause significant change in serum levels of homocysteine, vitamin B12 and folic acid, and there was no effect of age, sex or dietary pattern on homocy steine levels.

Vitamin B12 and Folate Status in Patients with Epilepsy Under Levetiracetam Monotherapy

Treatment with levetiracetam in patients with epilepsy has no effect on the serum levels concentrations of homocysteine, vitamin B12, and folate and this medication is suggested for patients who use AEDs on a long-term basis and at high dosages.

Effects of Antiepileptic Drug Monotherapy on One-Carbon Metabolism and DNA Methylation in Patients with Epilepsy

The findings suggest that the effects of AED monotherapy on OCM may induce specific regions of DNA hypomethylation in epileptic patients under treatment with antiepileptic drugs (AEDs) and healthy controls.



Mechanism for reduction of serum folate by antiepileptic drugs during prolonged therapy

Plasma total homocysteine concentrations in epileptic patients taking anticonvulsants.

The effect of a subnormal vitamin B-6 status on homocysteine metabolism.

It is concluded that a vitamin B-6 deficiency may contribute to impaired transsulfuration and an abnormal methionine load test, which is associated with premature vascular disease.

Folate deficiency, anticonvulsant drugs, and psychiatric morbidity.

The course of the supplementation treatment with 5 mg folinic acid (or FOA) of four patients with FOA deficiency could be monitored psychopathometrically and all four patients showed an improvement in their well-being and the majority of measured variables of the cognitive performance.

Hyperhomocysteinaemia and endothelial dysfunction in young patients with peripheral arterial occlusive disease

Pyridoxine plus folic acid treatment normalizes homocysteine metabolism in virtually all patients, and appears to ameliorate endothelial dysfunction.

Vitamin B-12, vitamin B-6, and folate nutritional status in men with hyperhomocysteinemia.

Because hyperhomocysteinemia is implicated as a risk factor for premature occlusive vascular disease, appropriate vitamin therapy may be both efficient and cost-effective to control elevated plasma homocysteine concentrations.

Serum lipids and lipoproteins in patients treated with antiepileptic drugs.

Effects of anticonvulsant treatment and low levels of folate and thiamine on amine metabolites in cerebrospinal fluid.

A total of 157 epileptic patients were studied with respect to (1) biogenic amine precursors and metabolites in the CSF, (2) levels of folate and thiamine in the blood and CSF, (3) length of

Elevated Plasma Concentrations of Homocysteine in Antiepileptic Drug Treatment

The objective of the study was to test the hypothesis that antiepileptic drug (AED) treatment is associated with increased homocysteine plasma concentrations.

A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians.

OBJECTIVE To assess prospectively the risk of coronary heart disease associated with elevated plasma levels of homocyst(e)ine. DESIGN Nested case-control study using prospectively collected blood