Hyperhomocysteinemia in children treated with sodium valproate and carbamazepine

@article{Verrotti2000HyperhomocysteinemiaIC,
  title={Hyperhomocysteinemia in children treated with sodium valproate and carbamazepine},
  author={Alberto Verrotti and Raffaele Pascarella and Daniela Trotta and T. Giuva and Guido Morgese and Francesco Chiarelli},
  journal={Epilepsy Research},
  year={2000},
  volume={41},
  pages={253-257}
}

Hyperhomocysteinaemia in children receiving phenytoin and carbamazepine monotherapy: a cross-sectional observational study

Phenytoin or carbamazepine monotherapy for >6 months duration is associated with hyperhomocysteinaemia in 90% of North Indian children and Elevated homocysteine concentrations were normalised in these children with folic acid supplementation.

Homocysteine Levels in Epileptic Children Receiving Antiepileptic Drugs

Assessment of plasma homocysteine, serum vitamin B12, and folic acid levels in children receiving enzyme-inducing antiepileptic drugs in children with idiopathic epilepsy is recommended.

Effects of Oxcarbazepine on Plasma Homocysteine, Vitamin B12, Folic Acid Levels

To assess the effects of oxcarbazepine (OXC) on plasma Hcy, FA and vit B12 levels, 42 epileptic outpatients receiving AED therapy were selected and their levels were statistically compared with each other using one way ANOVA method.

Effect of carbamazepine therapy on homocysteine, vitamin B12 and folic acid levels in children with epilepsy

6 months of carbamazepine therapy did not cause significant change in serum levels of homocysteine, vitamin B12 and folic acid, and there was no effect of age, sex or dietary pattern on homocy steine levels.

Vitamin B12 and Folate Status in Patients with Epilepsy Under Levetiracetam Monotherapy

Treatment with levetiracetam in patients with epilepsy has no effect on the serum levels concentrations of homocysteine, vitamin B12, and folate and this medication is suggested for patients who use AEDs on a long-term basis and at high dosages.

Effects of Antiepileptic Drug Monotherapy on One-Carbon Metabolism and DNA Methylation in Patients with Epilepsy

The findings suggest that the effects of AED monotherapy on OCM may induce specific regions of DNA hypomethylation in epileptic patients under treatment with antiepileptic drugs (AEDs) and healthy controls.
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