Hyperhomocysteinemia impairs endothelium-derived hyperpolarizing factor-mediated vasorelaxation in transgenic cystathionine beta synthase-deficient mice.

@article{Cheng2011HyperhomocysteinemiaIE,
  title={Hyperhomocysteinemia impairs endothelium-derived hyperpolarizing factor-mediated vasorelaxation in transgenic cystathionine beta synthase-deficient mice.},
  author={Zhongjian Cheng and Xiaohua Jiang and Warren D Kruger and Domenico Pratic{\`o} and Haiya J. Sheth and Karthik Mallilankaraman and Muniswamy Madesh and Andrew I. Schafer and William Durante and Xiaofeng Yang and Hong Wang},
  journal={Blood},
  year={2011},
  volume={118 7},
  pages={
          1998-2006
        }
}
Hyperhomocysteinemia (HHcy) is associated with endothelial dysfunction (ED), but the mechanism is largely unknown. In this study, we investigated the role and mechanism of HHcy-induced ED in microvasculature in our newly established mouse model of severe HHcy (plasma total homocysteine, 169.5 μM). We found that severe HHcy impaired nitric oxide (NO)- and endothelium-derived hyperpolarizing factor (EDHF)-mediated, endothelium-dependent relaxations of small mesenteric arteries (SMAs). Endothelium… CONTINUE READING
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