Hyperhomocysteinemia and the development of chronic kidney disease in a general population: the Hisayama study.

@article{Ninomiya2004HyperhomocysteinemiaAT,
  title={Hyperhomocysteinemia and the development of chronic kidney disease in a general population: the Hisayama study.},
  author={Toshiharu Ninomiya and Yutaka Kiyohara and Michiaki Kubo and Yumihiro Tanizaki and Keiichi Tanaka and Ken Okubo and Hidetoshi Nakamura and Jun Hata and Yoshinori Oishi and Isao Kato and Hideki Hirakata and Mitsuo Iida},
  journal={American journal of kidney diseases : the official journal of the National Kidney Foundation},
  year={2004},
  volume={44 3},
  pages={437-45}
}
BACKGROUND Hyperhomocysteinemia has been linked with various atherosclerotic diseases, but has not been evaluated sufficiently as a risk factor for the development of chronic kidney disease (CKD) in the general population. METHODS To clarify this issue, we followed up 1,477 community-dwelling individuals without CKD, aged 40 years or older, for 5 years and examined the effects of baseline serum total homocysteine (tHcy) levels on the development of CKD. RESULTS During follow-up, 88 subjects… CONTINUE READING

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