Hyperhomocysteinemia and the MTHFR C677T polymorphism promote steatosis and fibrosis in chronic hepatitis C patients.

@article{Adinolfi2005HyperhomocysteinemiaAT,
  title={Hyperhomocysteinemia and the MTHFR C677T polymorphism promote steatosis and fibrosis in chronic hepatitis C patients.},
  author={Luigi Elio Adinolfi and Diego Ingrosso and Giuseppe Cesaro and Amelia Cimmino and Maria D'Ant{\`o} and Rosanna Capasso and Vincenzo Zappia and Giuseppe Ruggiero},
  journal={Hepatology},
  year={2005},
  volume={41 5},
  pages={995-1003}
}
The factors and mechanisms implicated in the development of hepatitis C virus (HCV)-related steatosis are unknown. Hyperhomocysteinemia causes steatosis, and the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism induces hyperhomocysteinemia. We investigated the role of these factors in the development of HCV-related steatosis and in the progression of chronic hepatitis C (CHC). One hundred sixteen CHC patients were evaluated for HAI, fibrosis and steatosis grades, body mass index… CONTINUE READING
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