Hyperhomocysteinemia and oxidative stress: time for a reality check?

@article{Jacobsen2000HyperhomocysteinemiaAO,
  title={Hyperhomocysteinemia and oxidative stress: time for a reality check?},
  author={Donald Weldon Jacobsen},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2000},
  volume={20 5},
  pages={
          1182-4
        }
}
Oxidative stress due to the production of intracellular and extracellular reactive oxygen species may be a major player in the pathogenesis of cardiovascular and other diseases. Because homocysteine and other thiols have pro-oxidant activity, the oxidant stress hypothesis is frequently invoked to explain the damaging effects of homocysteine on vascular cells and tissues. 1,2 However, the underlying mechanisms of homocysteine-induced vascular injury are still largely unknown in subjects with… CONTINUE READING

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