Hyperhomocysteinemia and its role in the development of atherosclerosis.

  title={Hyperhomocysteinemia and its role in the development of atherosclerosis.},
  author={A B Lawrence de Koning and Geoff H Werstuck and Ji Zhou and Richard C Austin},
  journal={Clinical biochemistry},
  volume={36 6},
Numerous epidemiological studies have demonstrated that hyperhomocysteinemia (HHcy) is a strong and independent risk factor for cardiovascular disease. HHcy can result from a deficiency in the enzymes or vitamin cofactors required for homocysteine metabolism. Several hypotheses have been proposed to explain the cellular mechanisms by which HHcy promotes… CONTINUE READING