Hyperhomocysteinemia and bleomycin hydrolase modulate the expression of mouse brain proteins involved in neurodegeneration.

@article{SuszyskaZajczyk2014HyperhomocysteinemiaAB,
  title={Hyperhomocysteinemia and bleomycin hydrolase modulate the expression of mouse brain proteins involved in neurodegeneration.},
  author={Joanna Suszyńska-Zajczyk and Magdalena Luczak and Lukasz Marczak and Hieronim Jakubowski},
  journal={Journal of Alzheimer's disease : JAD},
  year={2014},
  volume={40 3},
  pages={713-26}
}
Homocysteine (Hcy) is a risk factor for Alzheimer's disease (AD). Bleomycin hydrolase (BLMH) participates in Hcy metabolism and is also linked to AD. The inactivation of the Blmh gene in mice causes accumulation of Hcy-thiolactone in the brain and increases susceptibility to Hcy-thiolactone-induced seizures. To gain insight into brain-related Blmh function, we used two-dimensional IEF/SDS-PAGE gel electrophoresis and MALDI-TOF/TOF mass spectrometry to examine brain proteomes of Blmh-/- mice and… CONTINUE READING