Corpus ID: 212555878

Hyperhomocysteinemia and DNA hypomethylation leading to reduced monoamines synthesis in depression: A case-control study

  title={Hyperhomocysteinemia and DNA hypomethylation leading to reduced monoamines synthesis in depression: A case-control study},
  author={Rinki Kumari and Aruna Agrawal and G. P. I. Singh and Gyan Prakash Dubey},
Background: Numerous studies have shown hyperhomocysteinemia (HHcy) associated with cardiovascular disease, neurodegenerative and neuropsychiatric disease such as clinical depression disorder through DNA hypomethylation and reduced level of monoamines. Objective: We performed this study to investigate the role of total levels of plasma homocysteine (tHcy), folate vitamin B12, and neurochemicals in depressive patients and compared them with healthy controls and also performed the relationship… Expand

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