Hyperhomocysteinemia, oxidative stress, and cerebral vascular dysfunction.


An elevated circulating concentration of the sulfurcontaining amino acid homocysteine, hyperhomocysteinemia, produces complex changes within the blood vessel wall. In the peripheral circulation, these changes include oxidative stress, proinflammatory effects such as expression of tumor necrosis factorand inducible nitric oxide (NO) synthase (iNOS), and… (More)


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