Hyperhomocyst(e)inemia and a common methylenetetrahydrofolate reductase mutation (Ala223Val MTHFR) in patients with inherited thrombophilic coagulation defects.

@article{Legnani1997HyperhomocysteinemiaAA,
  title={Hyperhomocyst(e)inemia and a common methylenetetrahydrofolate reductase mutation (Ala223Val MTHFR) in patients with inherited thrombophilic coagulation defects.},
  author={Cristina Legnani and Gualtiero Palareti and F. Grauso and Simonetta Sassi and Gianfranco i 77 Grygoryev Grossi and Sandro Piazzi and Francesco Bernardi and Giovanna Marchetti and Paolo Ferraresi and Sergio Coccheri},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={1997},
  volume={17 11},
  pages={2924-9}
}
To assess whether certain abnormalities of the sulfated amino acid metabolism are associated with the occurrence of thromboembolic events in patients with inherited thrombophilic conditions, the levels of homocyst(e)ine, before or after methionine load, and the presence of the Ala223Val substitution in the 5,10-methylenetetrahydrofolate reductase (MTHFR) were evaluated in 119 subjects with a congenital single thrombophilic condition (type I deficiency of antithrombin n = 10, protein C n = 24… CONTINUE READING

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